Priority 10 from the Mitochondrial Disease PSP

UNCERTAINTY: What are the most effective ways to treat and manage fatigue? (JLA PSP Priority 10)
Overall ranking	10
JLA question ID	0095/10
Explanatory note	Not available
Evidence	https://www.ncbi.nlm.nih.gov/pubmed?term=(%22Fatigue%2Fgenetics%22%5BMeSH%20Terms%5D)%20AND%20%22Mitochondrial%20Diseases%2Fdiagnosis%22%5BMAJR%5D
Health Research Classification System category	Metabolic and Endocrine

Extra information provided by this PSP
Original uncertainty examples	Alleviating symptoms such as fatigue ~ Mitochondria disease is untreatable but more information on treating symptoms- more energy ~ Is there likely to be a treatment to help with energy levels? ~ How much and what type of energy dense foods are most effective in managing fatigue. ~ CoQ10 placebo controlled double blind crossover study for fatigue ~ How to help him with energy levels ~ Ongoing research into medications to manage symptoms (fatigue for example) physical treatments
Submitted by	6 x Patients, 5 x Healthcare Professionals, 1 x Carers

Extra information provided by this PSP

Original uncertainty examples

Alleviating symptoms such as fatigue ~ Mitochondria disease is untreatable but more information on treating symptoms- more energy ~ Is there likely to be a treatment to help with energy levels? ~ How much and what type of energy dense foods are most effective in managing fatigue. ~ CoQ10 placebo controlled double blind crossover study for fatigue ~ How to help him with energy levels ~ Ongoing research into medications to manage symptoms (fatigue for example) physical treatments

Submitted by

6 x Patients, 5 x Healthcare Professionals, 1 x Carers

PSP information
PSP unique ID	0095
PSP name	Mitochondrial Disease
Total number of uncertainties identified by this PSP.	42 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	19 January 2020